A 43-kDa TDP-43 species is present in aggregates associated with frontotemporal lobar degeneration.
The transactive response DNA-binding protein (TDP-43) is a major click here component of the abnormal intracellular inclusions that occur in two common neurodegenerative diseases of humans: (1) a subtype of frontotemporal lobar degeneration and (2) amyotrophic lateral sclerosis.Genetics, experiments in cultured cells and animals, and analogy with o